The past few days have been really special for me and many others who were fortunate to celebrate Professor Wing Hung Wong’s birthday. He turned 70 and a symposium on Statistics and Data Science in Bioinformatics and Biomedicine was held at Stanford, where the speakers were mainly his former PhDs and Postdocs. It was a precious opportunity for me to talk to so many outstanding Wonglab alumni, who are now professors at Harvard, Berkeley, Duke, U Penn, Michigan, UCAL, UCSD, etc. I also felt very lucky to talk to many pioneers, such as Michael Waterman. As I accompanied Michael and several other professors back to hotel, I was reminded of the time when I learned the Smith-Waterman algorithm as a beginner in the field of computational biology.